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Posted at Apr 18, 2012 by JG

Dentistry and molecular biology: a promising field for tooth agenesis management » ncbi.nlm.nih.gov

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Tooth agenesis is the failure of tooth bud development, causing definitive absence of the tooth. It is the most common dental anomaly, affecting up to one-quarter of the general population. The main cause is related to abnormal function of specific genes which play key roles during odontogenesis, particularly MSX1 and PAX9. MSX1 is a transcription factor highly expressed in the mesenchyme of developing tooth germs, whereas PAX9 is a transcription factor that shows a direct relationship with craniofacial development, particularly the formation of the palate and teeth. Despite the high frequency of tooth agenesis, there are as yet only a restricted number of mutations in MSX1 and PAX9 that have been associated with non-syndromic tooth agenesis.

Read more:
http://www.ncbi.nlm.nih.gov/pubmed/22452934?dopt=Abstract

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